Methacholine challenge and sputum induction
نویسندگان
چکیده
منابع مشابه
Effect of methacholine challenge on cellular composition of sputum induction.
BACKGROUND Induced sputum and methacholine inhalation challenge are routinely used for the assessment of airway inflammation and airway hyperresponsiveness, respectively. This study investigates whether a methacholine challenge performed one hour before sputum induction alters the cellular and biochemical constituents of sputum. METHODS Sixteen stable asthmatic patients with lung function wit...
متن کاملConflicting methacholine challenge tests.
An 11-year-old boy experienced almost daily wheezing, dyspnea on exertion, and sleep perturbation because of cough. In addition, nadir peak expiratory flow (PEF) was below 100 L/min, which was 30% of predicted (328 L/min),1 compatible with severe persistent asthma.2 After the initiation of therapy with 180 g of albuterol 3 times per day, the patient’s domiciliary PEF rose to 200 L/min and his s...
متن کاملMethacholine challenge: test-shortening procedures.
STUDY OBJECTIVES Validation of test-shortening procedures for the 2-min tidal breathing methacholine challenge method. DESIGN Retrospective chart review. SETTING Tertiary-care university clinical pulmonary function laboratory. PATIENTS One thousand subjects aged 10 to 85 years (mean +/- SD, 44.5 +/- 16.0 years), 44.5% male, referred for methacholine challenge. INTERVENTION Two-minute ti...
متن کاملDevelopment of a methacholine challenge method to minimize methacholine waste.
BACKGROUND The standard 2-min tidal breathing methacholine challenge utilizes 3 mL to produce an output of 0.26 mL per 2 min, resulting in a substantial amount of methacholine being discarded. OBJECTIVE To develop a method with reduced methacholine waste and to compare it to the standard method. METHODS Twelve subjects with mild, well-controlled asthma volunteered for this investigation. Th...
متن کاملMethacholine challenge: comparison of two methods.
BACKGROUND Guidelines for the 2-min tidal-breathing and the five-breath dosimeter methods for methacholine challenge have recently been published by the American Thoracic Society (ATS). Although subjects are exposed to twice as much aerosol at any given concentration during the tidal-breathing method compared to the dosimeter method, they were thought to give equivalent results. OBJECTIVE To ...
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ژورنال
عنوان ژورنال: Thorax
سال: 1999
ISSN: 0040-6376
DOI: 10.1136/thx.54.8.750e